Coursework Example | Topics and Well Written Essays - 1000 words - 1

Coursework Example More water is needed to break bonds as hydrate contains hydrogen bonds between the water molecules. Anhydrous has faster dissolution rate forming a supersaturated solution within a shorter period of time (British pharmacopein, 2012). Theophylline is often manufactured in a modified – release formulations because of its characteristic of having a narrow therapeutic range. It is, thus, given at right doses. Modified release formulation would provide need to be provided at every 12 hours of enough plasma concentration. Peak serum-theophylline concentration occurs 4 hours after ingestion, which means formulation can release the drug at the right time. An overdose may be toxic. This imply that the formulation can provide constant release of the drug. (British Pharmacopein, 2012). Talc acts as a dissolution retardant and as a lubricant, Povidine (k25) acts as binder, Hydroxyethylcellulose acts as a binder, with Nuelin SA, acting as a plasticizer and as a surfactant (Raymond & Paul, 2012). Basing on the results in the spreadsheet, it is certain that Uniphyllin 300 mg had the slowest rate of release in different media (both HCL and phosphate dissolution buffer media). It was found out that Nueclin SA contained higher rate of release than Uniphyllin 300 in both phosphate and HCL buffer media. The percent release Uniphyllin 300mg in 0.1 HCL was 33.10% at 180 min, whereas percentage release of Neulin SA 250 mg in 0.1 HCL was 60.12 percent at 180 min of Uniphyllin 300mg in phosphate buffer was 34.85% at 180min, while percentage release of Nuelin SA 250 in phosphate buffer was 67.12% at 180min (Raymond & Paul, 2012). From the results obtained, it is quite clear that Nuelin SA 250 displayed PH-dependant drug release rate. The PH dependent gradient release is due to cellulose acetate phthalate. Cellulose acetate phthalate is used as an enteric coating on capsules or the tablets so that they do not dissolve until they are within the stomach acidic juicesof